Metallo-β-lactamase-IN-16

Metallo-β-lactamase-IN-16

• CAS Number: 2058069-25-1
• UNSPSC Description: Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively[1].
• Target Antigen: Bacterial; Beta-lactamase
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/metallo-β-lactamase-in-16.html
• Smiles: NCCS(=O)(C1=CC=C(C(C2=NNN=N2)=C1S(N)(=O)=O)C3=CC=CC4=C3N=C(S4)N)=O
• Molecular Weight: 480.54
• References & Citations: [1]Frank Bennett, et al. Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues. Bioorg Med Chem Lett. 2024 Oct 11:114:129989.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported