Metallo-β-lactamase-IN-5

Metallo-β-lactamase-IN-5

• CAS Number: 1417737-65-5
• UNSPSC Description: Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity[1].
• Target Antigen: Apoptosis; Bacterial; Beta-lactamase
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/metallo-β-lactamase-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: N#CCN(CC1=CC([N+]([O-])=O)=C2C=CC=NC2=C1O)CC3=CC=CC=C3
• Molecular Weight: 348.36
• References & Citations: [1]Proschak A, Martinelli G, Frank D, Rotter MJ, Brunst S, Weizel L, Burgers LD, Fürst R, Proschak E, Sosič I, Gobec S, Wichelhaus TA. Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases. Eur J Med Chem. 2022 Jan 15;228:113975.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported