Metallo-β-lactamase-IN-6

Metallo-β-lactamase-IN-6

• CAS Number: 1439899-44-1
• UNSPSC Description: Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL[1].
• Target Antigen: Bacterial; Beta-lactamase
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/metallo-β-lactamase-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=NC=CN1CC2=CC=NC=C2)O
• Molecular Weight: 203.20
• References & Citations: [1]Yan YH, Li W, Chen W, et al. Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors. Eur J Med Chem. 2022;228:113965.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported