A1AR antagonist 2

A1AR antagonist 2

• CAS Number: 1441961-74-5
• UNSPSC Description: A1AR antagonist 2 (compound 18h) is a potent A1 adenosine receptor (AR) antagonist with Kis of 1.49, 10.2, and 50.1 nM for hA1, hA2A and hA2B, respectively[1].
• Target Antigen: Adenosine Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/a1ar-antagonist-2.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=C(C2=CC=CC=C2)N=C(N)N=C1C3=CC=CC(O)=C3
• Molecular Weight: 288.30
• References & Citations: [1]Val C, et al. Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists. J Med Chem. 2022;65(3):2091-2106.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported