PCSK9 modulator-2

PCSK9 modulator-2

• CAS Number: 2365416-53-9
• UNSPSC Description: PCSK9 modulator-2 (Compound 1) is a potent modulator of PCSK9 with an EC50 value of 202 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-2 has the potential for the research of hyperlipidemia[1].
• Target Antigen: PCSK9
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/pcsk9-modulator-2.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CC=CC2=C1NC=C2CC3=CC4=CC(F)=CC=C4N3
• Molecular Weight: 282.29
• References & Citations: [1]Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported