PCSK9 modulator-4

PCSK9 modulator-4

• CAS Number: 2476490-20-5
• UNSPSC Description: PCSK9 modulator-4 (Compound 21) is a potent modulator of PCSK9 with an EC50 value of 0.15 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-4 has the potential for the research of hyperlipidemia[1].
• Target Antigen: PCSK9
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/pcsk9-modulator-4.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CNC2=C1C=CC=C2F)C3=NC4=CC=C(F)C=C4N3C
• Molecular Weight: 311.29
• References & Citations: [1] Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported