STAT6 Polyclonal Antibody

STAT6 Polyclonal Antibody

• Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
• Synonyms: D12S1644,IL-4-STAT,STAT6B,STAT6C,STAT6
• CAS Number: 9007-83-4
• Gene ID: 6778
• Swiss Prot: P42226
• Host: Rabbit
• Reactivity: Human,Mouse,Rat
• Immunogen: Recombinant fusion protein of human STAT6 (NP_001171550.1).
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: WB
• Purification: Affinity purification
• Concentration: 1 mg/mL
• Dilution: WB 1:500-1:2000
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.
• Calculated Molecular Weight: 74 kDa/81 kDa/94 kDa
• Observed Molecular Weight: 110 kDa