Recombinant Mouse B7-H4/VTCN1 Protein (Fc Tag)

Recombinant Mouse B7-H4/VTCN1 Protein (Fc Tag)

• Background: Mouse V-set domain-containing T-cell activation inhibitor 1/VTCN1/B7-H4 is glycosylated member of the B7 family of immune co-stimulatory proteins. B7-H4 consists of extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
• Abbreviation: B7-H4;VTCN1
• Synonyms: B7 homolog 4, B7-H4, B7h4, B7s1, B7x, BC032925, Protein B7S1, V-set domain containing T-cell activation inhibitor 1, VTCN1
• CAS Number: 9000-83-3
• UniProt: Q7TSP5
• Accession Number: AAH32925.1
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-Fc
• Sequence: Phe29-Pro258
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 70-90 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.