Recombinant Human B7-H4/VTCN1 Protein (mFc Tag)

Recombinant Human B7-H4/VTCN1 Protein (mFc Tag)

• Background: B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains; a 21 aa transmembrane segment; and a 2 aa cytoplasmic tail. It is widely expressed; including in kidney; liver; lung; pancreas; placenta; prostate; spleen; testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation; proliferation; cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages; plays an important role; together with regulatory T-cells (Treg); in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
• Abbreviation: B7-H4;VTCN1
• Synonyms: B7-H4, B7H4T-cell costimulatory molecule B7x, B7S1, B7S1VCTN1, B7XPRO1291, B7h.5, B7x, FLJ22418, Immune costimulatory protein B7-H4, Protein B7S1, T cell costimulatory molecule B7x, V-set domain containing T cell activation inhibitor 1, V-set domain-containing , Vtcn1
• CAS Number: 9000-83-3
• UniProt: Q7Z7D3
• Accession Number: Q7Z7D3
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-mFc
• Sequence: Phe29-Ala258
• Field of Research: Cell biology;Cancer;immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 66-105 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.