Azido-PEG4-Val-Cit-PAB-MMAE

Azido-PEG4-Val-Cit-PAB-MMAE

• CAS Number: 1869126-64-6
• UNSPSC Description: Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH[1]. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/azido-peg4-val-cit-pab-mmae.html
• Purity: 99.36
• Solubility: H2O : < 0.1 mg/mL (ultrasonic;adjust pH to 4 with 0.01 M Acetic acid)
• Smiles: O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)=O)=O)=O)=O)OC)=O
• Molecular Weight: 1396.71
• References & Citations: [1]Moreadith R, et, al. Polyoxazoline antibody drug conjugates. WO2016019340A1.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, protect from light, stored under nitrogen)
• Clinical Information: No Development Reported