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Azido-PEG4-Val-Cit-PAB-MMAE

CAT:
804-HY-W190943-01
Size:
1 mg
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Azido-PEG4-Val-Cit-PAB-MMAE - image 1

Azido-PEG4-Val-Cit-PAB-MMAE

  • CAS Number: 1869126-64-6
  • UNSPSC Description: Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH[1]. Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • Target Antigen: Drug-Linker Conjugates for ADC
  • Type: ADC Related
  • Related Pathways: Antibody-drug Conjugate/ADC Related
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/azido-peg4-val-cit-pab-mmae.html
  • Purity: 99.36
  • Solubility: H2O : < 0.1 mg/mL (ultrasonic;adjust pH to 4 with 0.01 M Acetic acid)
  • Smiles: O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)=O)=O)=O)=O)OC)=O
  • Molecular Weight: 1396.71
  • References & Citations: [1]Moreadith R, et, al. Polyoxazoline antibody drug conjugates. WO2016019340A1.
  • Shipping Conditions: Blue Ice
  • Storage Conditions: -20°C (Powder, protect from light, stored under nitrogen)
  • Clinical Information: No Development Reported