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TLR4/NF-κB-IN-1

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804-HY-168710
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
TLR4/NF-κB-IN-1 - image 1

TLR4/NF-κB-IN-1

  • UNSPSC Description: TLR4/NF-κB-IN-1 (Compound 7x) is an orally available inhibitor that specifically targets the TLR4/NF-κB signaling pathway, offering anti-inflammatory effects and the ability to cross the blood-brain barrier. TLR4/NF-κB-IN-1 can reduce acute neuroinflammation in mice caused by LPS (HY-D1056) and downregulate the expression of TLR4, P-NF-κB and P-IκB-α proteins[1].
  • Target Antigen: IKK; NF-κB; Toll-like Receptor (TLR)
  • Type: Reference compound
  • Related Pathways: Immunology/Inflammation;NF-κB
  • Field of Research: Inflammation/Immunology
  • Assay Protocol: https://www.medchemexpress.com/tlr4-nf-κb-in-1.html
  • Smiles: FC1=CC=C(CN2C=CC3=C(NC4=CC(NC(N5)=O)=C5C=C4)N=CN=C32)C=C1
  • Molecular Weight: 374.37
  • References & Citations: [1]Liang Xiong, et al. Design and synthesis of novel derivatives of bisepoxylignans as potent anti-inflammatory agents involves the modulation of the M1/M2 microglia phenotype via TLR4/NF-κB signaling pathway. Eur J Med Chem. 2025 Jan 15:282:117092.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported