ABT-046

ABT-046

• CAS Number: 1031336-60-3
• UNSPSC Description: ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of both 8 nM against human and mouse DGAT-1[1].
• Target Antigen: Acyltransferase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/abt-046.html
• Solubility: DMSO : 66.67 mg/mL (ultrasonic)
• Smiles: NC1=C(C2=CC=C([C@H]3CC[C@H](CC(O)=O)CC3)C=C2)C=NC4=CC=NN41
• Molecular Weight: 350.41
• References & Citations: [1]Yeh VS, et al. Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of Acyl-CoA: Diacylglycerol acyltransferase 1. J Med Chem. 2012 Feb 23;55(4):1751-1757.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported