BM-962

BM-962

• CAS Number: 1391107-57-5
• UNSPSC Description: BM-962 (Compound 31) is a potent small-molecule inhibitor of Bcl-2 with an IC50 value of 4 nM (Ki=0.8 nM) and Bcl-xL with an IC50 value of 3.9 nM (Ki IC50 values of 9 and 13 nM, respectively. BM-962 is promising for research of cancers[1][2].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bm-962.html
• Smiles: OC(C1=C(C)N(C(C)C)C(C2=CC=C(C=C2)Cl)=C1C3=CC(N4CCN(C5=CC=C(C=C5)NS(=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCC(CC8)O)=O)CC4)=CC=C3)=O
• Molecular Weight: 1079.71
• References & Citations: [1]Chen J, et al. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem. 2012 Oct 11;55(19):8502-14.|[2]Wang SM, et al. Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same. US20120189539. 2012 July 26.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported