RI-962

RI-962

• CAS Number: 2763831-53-2
• UNSPSC Description: RI-962 is a potent and selective receptor-interacting protein kinase 1 (RIPK1) inhibitor. RI-962 inhibits RIPK1 with an IC50 value of 35.0?nM. RI-962 can be used for the research of nervous system diseases and inflammatory diseases[1].
• Target Antigen: Necroptosis; RIP kinase
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ri-962.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CN(C)C2=C1C=C(C3=CC4=NC(NC(C(C)C)=O)=NN4C=C3)C=C2)NC(C)C5=CC=CC=C5
• Molecular Weight: 480.56
• References & Citations: [1]Yueshan Li, et al. Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor. Nat Commun. 2022 Nov 12;13(1):6891.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported