Trifluoperazine (dihydrochloride)
CAT:
804-HY-B0532A-04
Size:
500 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Trifluoperazine (dihydrochloride)
- CAS Number: 440-17-5
- UNSPSC Description: Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].
- Target Antigen: Adrenergic Receptor; Autophagy; CaMK; Dopamine Receptor; Influenza Virus; P-glycoprotein
- Type: Reference compound
- Related Pathways: Anti-infection;Autophagy;GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
- Applications: Cancer-programmed cell death
- Field of Research: Neurological Disease; Cancer
- Assay Protocol: https://www.medchemexpress.com/trifluoperazine-dihydrochloride.html
- Purity: 99.98
- Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
- Smiles: FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F.Cl.Cl
- Molecular Weight: 480.42
- References & Citations: [1]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28.|[2]Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70.|[3]Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545.|[4]Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22.|[5]Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160.bioRxiv. 2024 June 12.|BMC Med Genomics. 2024 Jan 2;17(1):12.|CNS Neurosci Ther. 2023 Jan 10.|J Transl Med. 2024 Aug 1;22(1):715.|Mol Med Rep. 2021 Mar 3.|Chem Biol Interact. 2024 Feb 13:110904.|Food Biosci. 2024 Feb, 57, 103513.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched