Trifluoperazine

Trifluoperazine

• CAS Number: 117-89-5
• UNSPSC Description: Trifluoperazine, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine is a potent α1-adrenergic receptor antagonist. Trifluoperazine is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine can be used for the research of schizophrenia. Trifluoperazine acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].
• Target Antigen: Adrenergic Receptor; Autophagy; CaMK; Dopamine Receptor; Influenza Virus; P-glycoprotein
• Type: Reference compound
• Related Pathways: Anti-infection;Autophagy;GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: COVID-19-anti-virus
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/trifluoperazine.html
• Solubility: 10 mM in DMSO
• Smiles: FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F
• Molecular Weight: 407.50
• References & Citations: [1]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129(6):2500-2513. Published 2019 Mar 28.|[2]Marques LO, Lima MS, Soares BG. Trifluoperazine for schizophrenia. Cochrane Database Syst Rev. 2004;2004(1):CD003545.|[3]Howland RH. Trifluoperazine: A Sprightly Old Drug. J Psychosoc Nurs Ment Health Serv. 2016;54(1):20-22.|[4]Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA. Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol. 1983;23(1):67-70.|[5]Ochiai H, et al. Influence of trifluoperazine on the late stage of influenza virus infection in MDCK cells. Antiviral Res. 1991;15(2):149-160.Chem Biol Interact. 2024 Feb 13:110904.|Food Biosci. 2024 Feb, 57, 103513.|bioRxiv. 2024 June 12.|BMC Med Genomics. 2024 Jan 2;17(1):12.|CNS Neurosci Ther. 2023 Jan 10.|J Transl Med. 2024 Aug 1;22(1):715.|Mol Med Rep. 2021 Mar 3.
• Shipping Conditions: Room temperature
• Clinical Information: Launched