GRO-alpha/CXCL1, Human (CHO)

GRO-alpha/CXCL1, Human (CHO)

• UNSPSC Description: CXCL1 (Chemokine (C-X-C motif) ligand 1), also known as GRO alpha, NAP-3 or MGSA, belongs to the sub-family of CXC chemokine. CXCL1 is involved in the development of many inflammatory diseases, including the induction of angiogenesis and recruitment of neutrophils. CXCL1 is produced by many cell types, and activates CXCR2 and, at high levels, CXCR1[1]. GRO-alpha/CXCL1 Protein, Human (CHO) is produced in CHO cells, and consists of 73 amino acids (A35-N107).
• Type: Recombinant Proteins
• Applications: Neuroscience-Neuromodulation
• Assay Protocol: https://www.medchemexpress.com/cytokines/gro-alpha-cxcl1-protein-human-cho.html
• Purity: 98.0
• Smiles: ASVATELRCQ CLQTLQGIHP KNIQSVNVKS PGPHCAQTEV IATLKNGRKA CLNPASPIVK KIIEKMLNSD KSN
• Molecular Weight: Approximately 7.8 kDa
• References & Citations: [1]Bayo J, et al. IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness. Oncotarget. 2016 Jun 25;8(46):80235-80248.|[2]Hou SM, et al. CXCL1 contributes to IL-6 expression in osteoarthritis and rheumatoid arthritis synovial fibroblasts by CXCR2, c-Raf, MAPK, and AP-1 pathway. Arthritis Res Ther. 2020 Oct 21;22(1):251.|[3]Matsuo Y, et al. CXC‐chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer[J]. International journal of cancer, 2009 Feb, 125(5): 1027-1037.
• Shipping Conditions: Blue Ice
• Storage Conditions: Stored at -20°C for 2 years