Cynomolgus Glypican 3 / GPC3 Protein, Llama IgG2b Fc Tag, low endotoxin

Cynomolgus Glypican 3 / GPC3 Protein, Llama IgG2b Fc Tag, low endotoxin

• Background: Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.
• Description: Cynomolgus Glypican 3, Llama IgG2b Fc Tag, low endotoxin (GP3-C5259) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - His 559 (Accession # XP_005594665.1).
• Specifications: This protein carries a llama IgG2b Fc tag at the C-terminus. This protein contains a furin-like convertase cleavage site, 355-RQYR-358, and will be partially processed into N and C-terminal fragment with calculated MW of 38.1 kDa and 50.5 kDa respectively. The protein migrates as 40 kDa, 60 kDa and 100-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expression Region: Gln 25 - His 559
• Host: HEK 293
• Target: Glypican 3
• Conjugation: Unconjugated
• Tag: C-LlamaFc(LlamaIgG2b)
• Source: Cynomolgus
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 0.01 EU per μg
• Purity: 90%
• Bioactivity: Immobilized Cynomolgus Glypican 3 Protein, Llama IgG2b Fc Tag (Cat. No. GP3-C5259) at 1 μg/mL (100 μL/well) can bind Anti-hGPC3 antibody, Human IgG1 with a linear range of 0.5-8 ng/mL (QC tested).
• Format: Powder
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Additives: Trehalose
• Molecular Weight: 38.1 kDa and 50.5 kDa
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C