Alpha Catenin Antibody

Alpha Catenin Antibody

• Description: Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-Catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-Catenin forms a heterodimer with beta-Catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-Catenin also regulates the beta-Catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer.
• CAS Number: 9007-83-4
• UniProt: P35221
• Host: Mouse
• Immunogen: A human fusion protein was used as the immunogen for the Alpha Catenin antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: FACS, IF, WB
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Store the Alpha Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This Alpha Catenin antibody is available for research use only.