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Catenin delta 1 Antibody / CTNND1 / p120 Catenin

CAT:
800-V9520SAF-100UG
Size:
100 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
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Catenin delta 1 Antibody / CTNND1 / p120 Catenin

  • Description: Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins. p120 is a proliferation-associated nucleolar protein found in most human malignant tumors, but not in resting normal cells. In colorectal cancer the altered localization of p120 catenin corresponds with loss of cytoplasmic localization of E-cadherin. Studies have shown accurate categorization of ductal vs. lobular neoplasia in the breast was achieved with p120 staining. p120 expression further clarifies the separation of low-grade ductal carcinoma in situ from lobular neoplasia. Studies also have shown that altered expression of p120 catenin antibody predicts poor outcome in invasive breast cancer.
  • CAS Number: 9007-83-4
  • UniProt: O60716
  • Host: Mouse
  • Immunogen: A portion of amino acids 100-300 was used as the immunogen for the Catenin delta 1 antibody.
  • Clonality: Monoclonal
  • Isotype: IgG1 κ
  • Applications: IHC-P
  • Format: Purified
  • Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
  • Reconstitution: Aliquot the Catenin delta 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • Limitations: This Catenin delta 1 antibody is available for research use only.