(αR)-Cyclopropaneacetamide-Exatecan

(αR)-Cyclopropaneacetamide-Exatecan

• CAS Number: 2414254-37-6
• UNSPSC Description: (αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, is a cytotoxic agent. (αR)-Cyclopropaneacetamide-Exatecan inhibits U87MG and SK-BR-3 cells proliferation, with IC50s of 8.11 and 2.31 μM[1].
• Target Antigen: ADC Cytotoxin; Topoisomerase
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/αr-cyclopropaneacetamide-exatecan.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O[C@H](C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O
• Molecular Weight: 533.55
• References & Citations: [1]Haiqing H, et, al. Antibody-drug conjugate and medical use thereof. WO2021190564A1.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported