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(αR)-Cyclopropaneacetamide-Exatecan

CAT:
804-HY-156617A-01
Size:
1 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
(αR)-Cyclopropaneacetamide-Exatecan - image 1

(αR)-Cyclopropaneacetamide-Exatecan

  • CAS Number: 2414254-37-6
  • UNSPSC Description: (αR)-Cyclopropaneacetamide-Exatecan (compound 2-A), an Exenotecan derivative, is a cytotoxic agent. (αR)-Cyclopropaneacetamide-Exatecan inhibits U87MG and SK-BR-3 cells proliferation, with IC50s of 8.11 and 2.31 μM[1].
  • Target Antigen: ADC Cytotoxin; Topoisomerase
  • Type: Reference compound
  • Related Pathways: Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
  • Applications: Cancer-programmed cell death
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/αr-cyclopropaneacetamide-exatecan.html
  • Solubility: DMSO : 100 mg/mL (ultrasonic)
  • Smiles: O[C@H](C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O
  • Molecular Weight: 533.55
  • References & Citations: [1]Haiqing H, et, al. Antibody-drug conjugate and medical use thereof. WO2021190564A1.
  • Shipping Conditions: Room Temperature
  • Clinical Information: No Development Reported