JQ-1 (carboxylic acid)

JQ-1 (carboxylic acid)

• CAS Number: 202592-23-2
• UNSPSC Description: JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4.
• Target Antigen: Epigenetic Reader Domain; PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Epigenetics;Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/JQ-1-carboxylic-acid.html
• Purity: 99.82
• Solubility: DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[C@H]4CC(O)=O)C=C1
• Molecular Weight: 400.88
• References & Citations: [1]Huang Y, et, al. Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation. Bioconjug Chem. 2022 Jan 19;33(1):142-151.|[2]Chen W, et, al. Dual drugs decorated bacteria irradiate deep hypoxic tumor and arouse strong immune responses. Biomaterials. 2022 Jul;286:121582.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported