JQ-1 (carboxylic acid)-NH-C2-NH-COOH

JQ-1 (carboxylic acid)-NH-C2-NH-COOH

• UNSPSC Description: JQ-1 (carboxylic acid)-NH-C2-NH-COOH is a conjugate of E3 ligase ligand and linker (E3 Ligase Ligand-Linker Conjugates), which is composed of JQ-1 carboxylic acid (HY-78695) and the corresponding linker: (2-Aminoethyl)carbamic acid (HY-W398806). JQ-1 (carboxylic acid)-NH-C2-NH-COOH can be used as a Cereblon ligand to recruit CRBN protein and as a key intermediate for the synthesis of complete PROTACs molecules[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/jq-1-carboxylic-acid-nh-c2-nh-cooh.html
• Smiles: O=C(O)NCCNC(C[C@@H]1N=C(C2=C(N3C(C)=NN=C13)SC(C)=C2C)C4=CC=C(C=C4)Cl)=O
• Molecular Weight: 486.97
• References & Citations: [1]Qian Shao, et al. "Targeted Protein Localization by Covalent 14–3–3 Recruitment." Journal of the American Chemical Society (2024).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported