(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
CAT:
804-HY-76104-02
Size:
100 g
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
- CAS Number: 77449-94-6
- UNSPSC Description: cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
- Target Antigen: ADC Linker; PROTAC Linkers
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/cis-4-hydroxy-d-proline-hydrochloride.html
- Purity: 98.0
- Solubility: 10 mM in DMSO
- Smiles: OC([C@H]1C[C@H](CN1)O)=O.Cl
- Molecular Weight: 167.59
- References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported