(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride

(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride

• CAS Number: 77449-94-6
• UNSPSC Description: cis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
• Target Antigen: ADC Linker; PROTAC Linkers
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cis-4-hydroxy-d-proline-hydrochloride.html
• Purity: 98.0
• Solubility: 10 mM in DMSO
• Smiles: OC([C@H]1C[C@H](CN1)O)=O.Cl
• Molecular Weight: 167.59
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported