EPZ011989 (trifluoroacetate)

EPZ011989 (trifluoroacetate)

• CAS Number: 1598383-41-5
• UNSPSC Description: EPZ-011989 trifluoroacetate is a potent and orally active Zeste Homolog 2 (EZH2) inhibitor with metabolic stability. EPZ-011989 trifluoroacetate has inhibitory inhibition for EZH2 with a Ki value of [1]. EPZ011989 (trifluoroacetate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/EPZ011989-trifluoroacetate.html
• Purity: 98.71
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(C#CCN3CCOCC3)=CC(N(CC)[C@H]4CC[C@H](N(CCOC)C)CC4)=C2C.O=C(O)C(F)(F)F
• Molecular Weight: 719.83
• References & Citations: [1]Campbell JE, et al. EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity. ACS Med Chem Lett. 2015 Mar 4;6(5):491-495.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported