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Folinic acid-d4 (calcium hydrate)

CAT:
804-HY-17556S1
Size:
250 µg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Folinic acid-d4 (calcium hydrate) - image 1

Folinic acid-d4 (calcium hydrate)

  • UNSPSC Description: Folinic acid-d4-1 (Leucovorin-d4-1) calcium hydrate is deuterated labeled Folinic acid (HY-17556). Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
  • Target Antigen: Antifolate; Endogenous Metabolite; Isotope-Labeled Compounds
  • Type: Isotope-Labeled Compounds
  • Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others
  • Applications: Cancer-programmed cell death
  • Field of Research: Cancer
  • Purity: 91.69
  • Solubility: DMSO : 250 mg/mL (ultrasonic;warming)
  • Smiles: O=C([O-])CC[C@@H](C([O-])=O)NC(C1=CC=C(NC([2H])([2H])C2([2H])N(C=O)C3=C(NC(N)=NC3=O)NC2[2H])C=C1)=O.[F,Cl,Br,I].O.[Ca+2]
  • References & Citations: [1]Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.|[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
  • Shipping Conditions: Blue Ice
  • Storage Conditions: -20°C (Powder, stored under nitrogen, away from moisture)
  • Clinical Information: No Development Reported