Folinic acid
CAT:
804-HY-17556-06
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Folinic acid
- CAS Number: 58-05-9
- UNSPSC Description: Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1].
- Target Antigen: Antifolate; Endogenous Metabolite
- Type: Natural Products
- Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/folinic-acid.html
- Solubility: DMSO : 250 mg/mL (ultrasonic)
- Smiles: O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C=O)C3=C(N=C(N)NC3=O)NC2)C=C1)=O
- Molecular Weight: 473.44
- References & Citations: [1]Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.|[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.Appl Microbiol Biotechnol. 2024 Dec;108(1):1-15.|bioRxiv. 2023 Feb 28.|JAMA Oncol. 2022 Jan 1;8(1):e215445.|Mol Oncol. 2020 Nov;14(11):2894-2919.|NPJ Precis Oncol. 2023 Dec 8;7(1):128.|Patent. US20230101335A1.|Virology. 2023 Jun 21.|EBioMedicine. 2024 Mar 13:102:105041.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Nat Commun. 2020 Apr 14;11(1):1792.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
- Shipping Conditions: Blue Ice
- Clinical Information: Launched