Tolvaptan phosphate ester (sodium)
CAT:
804-HY-157220
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Tolvaptan phosphate ester (sodium)
- CAS Number: 942619-79-6
- UNSPSC Description: Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation[1][2].
- Target Antigen: Vasopressin Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein
- Applications: Neuroscience-Neuromodulation
- Field of Research: Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/tolvaptan-phosphate-ester-sodium.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=C(C)C=CC=C1)NC2=CC=C(C(C)=C2)C(N3C4=CC=C(C=C4C(CCC3)OP(O[Na])(O[Na])=O)Cl)=O
- Molecular Weight: 572.88
- References & Citations: [1]Hiroyuki Fujiki, et al. In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan. J Pharmacol Sci. 2022 Nov;150(3):163-172.|[2]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported