Tolvaptan

Tolvaptan

• CAS Number: 150683-30-0
• UNSPSC Description: Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. Tolvaptan induces cell apoposis and affects cell cycle. Tolvaptan can be used for the research of hyponatremia[1][2].
• Target Antigen: Autophagy; Vasopressin Receptor
• Type: Reference compound
• Related Pathways: Autophagy;GPCR/G Protein
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease; Endocrinology; Cancer
• Assay Protocol: https://www.medchemexpress.com/Tolvaptan.html
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: O=C(C1=CC=CC=C1C)NC2=CC=C(C(C)=C2)C(N3CCCC(C4=CC(Cl)=CC=C43)O)=O
• Molecular Weight: 448.94
• References & Citations: [1]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36.|[2]El-Shabrawy M, et al. Protective effect of tolvaptan against cyclophosphamide-induced nephrotoxicity in rat models. Pharmacol Res Perspect. 2020 Oct;8(5):e00659.
• Shipping Conditions: Room Temperature
• Clinical Information: Launched