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6-S-(2-Cyanoethyl)-2’-deoxy-5’-O-DMTr--6-thioguanosine 3’-CED phosphoramidite

CAT:
804-HY-154617
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
6-S-(2-Cyanoethyl)-2’-deoxy-5’-O-DMTr--6-thioguanosine 3’-CED phosphoramidite - image 1

6-S-(2-Cyanoethyl)-2’-deoxy-5’-O-DMTr--6-thioguanosine 3’-CED phosphoramidite

  • UNSPSC Description: 6-S-(2-Cyanoethyl)-2’-deoxy-5’-O-DMTr--6-thioguanosine 3’-CED phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
  • Target Antigen: Nucleoside Antimetabolite/Analog
  • Type: Oligonucleotides
  • Related Pathways: Cell Cycle/DNA Damage
  • Applications: Cancer-programmed cell death
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/6-s-2-cyanoethyl-2-deoxy-5-o-dmtr-6-thioguanosine-3-ced-phosphoramidite.html
  • Solubility: 10 mM in DMSO
  • Smiles: NC(N=C1SCCC#N)=NC2=C1N=CN2[C@@H]3O[C@H](COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C3
  • Molecular Weight: 838.95
  • References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported