S07-2005 (racemic)

S07-2005 (racemic)

• CAS Number: 1826337-40-9
• UNSPSC Description: S07-2005 racemic is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. S07-2005 racemic has potential as a chemotherapeutic potentiator for cancer agent resistance[1].
• Target Antigen: 17β-HSD
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s07-2005-racemic.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C(C)OC(CN(C)C(C2COC3=C(C=C(OCC)C=C3)C2)=O)=C1)O
• Molecular Weight: 373.40
• References & Citations: [1]Siyu He, et al. Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance. ACS Med. Chem. Lett. Jun 2022.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported