K858 (Racemic)
CAT:
804-HY-19966-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
K858 (Racemic)
- CAS Number: 72926-24-0
- UNSPSC Description: K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.
- Target Antigen: Apoptosis; Kinesin
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/K858.html
- Purity: 99.93
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CC(NC1=NN(C(C)=O)C(C2=CC=CC=C2)(C)S1)=O
- Molecular Weight: 277.349
- References & Citations: [1]Nakai R, et al. K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 2009 May 1;69(9):3901-9.|[2]De Iuliis F, et al. The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells. Invest New Drugs. 2016 Aug;34(4):399-406.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported