EGFR/HER2/DHFR-IN-3
CAT:
804-HY-149633
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
EGFR/HER2/DHFR-IN-3
- UNSPSC Description: EGFR/HER2/DHFR-IN-3 (compound 4c) is a potent dual inhibitor of EGFR/HER2, with IC50s of 0.138 and 0.092 μM, respectively. EGFR/HER2/DHFR-IN-3 also inhibits DHFR, with an IC50 of 0.193 M. EGFR/HER2/DHFR-IN-3 causes arrest at the S phase of the cell cycle and induces apoptosis in MCF7 breast cancer cells[1].
- Target Antigen: Apoptosis; Dihydrofolate reductase (DHFR) ; EGFR
- Type: Reference compound
- Related Pathways: Apoptosis;JAK/STAT Signaling;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/egfr-her2-dhfr-in-3.html
- Solubility: 10 mM in DMSO
- Smiles: N#CC1=C(OCCC)N=C(C2=CC=C(C)C=C2)C=C1C3=CC=C([N+]([O-])=O)C=C3
- Molecular Weight: 373.40
- References & Citations: [1]Hawas SS, et, al. New 2-alkoxycyanopyridine derivatives as inhibitors of EGFR, HER2, and DHFR: Synthesis, anticancer evaluation, and molecular modeling studies. Bioorg Chem. 2023 Sep 21:141:106874.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported