EGFR/HER2/CDK9-IN-3
CAT:
804-HY-147798
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
EGFR/HER2/CDK9-IN-3
- CAS Number: 422276-47-9
- UNSPSC Description: EGFR/HER2/CDK9-IN-3 (Compound 10) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 191.08, 132.65, and 113.98 nM, respectively. EGFR/HER2/CDK9-IN-3 exhibits remarkable antitumor activity[1].
- Target Antigen: CDK; EGFR
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/egfr-her2-cdk9-in-3.html
- Solubility: 10 mM in DMSO
- Smiles: O=S(C1=CC=C(CCN2C(SCC(C3=CC=CC=C3)=O)=NC4=C(C=CC=C4)C2=O)C=C1)(N)=O
- Molecular Weight: 479.57
- References & Citations: [1] El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported