Keap1-Nrf2-IN-10
CAT:
804-HY-147548
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Keap1-Nrf2-IN-10
- CAS Number: 2445349-54-0
- UNSPSC Description: Keap1-Nrf2-IN-10 (compound 15) is a potent NQO1 inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice[1].
- Target Antigen: Reactive Oxygen Species
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-10.html
- Solubility: 10 mM in DMSO
- Smiles: COC1=CC(NC(CSC2=NC3=C(C=C(C=C3C(N2C4=CC=C(C=C4)S(N)(=O)=O)=O)I)I)=O)=CC(OC)=C1OC
- Molecular Weight: 808.40
- References & Citations: [1]Soliman AM, et al. Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety. Eur J Med Chem. 2020 Aug 15;200:112467.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported