Keap1-Nrf2-IN-6

• UNSPSC Description:

  Keap1-Nrf2-IN-6 (compound 64) is a potent and selective Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 41 nM, Kd of 68 nM[1].

• Target Antigen:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/keap1-nrf2-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N[C@H](CSCC2=C(C(OC[C@H]1NC([C@@H]3CCCN3C(C)=O)=O)=O)C=CC=C2C4=CC=C(C=C4)C(O)=O)C(N(C)C)=O

• Molecular Weight:

  610.68

• References & Citations:

  [1]Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported