EGFR/HER2/TS-IN-2
CAT:
804-HY-146239
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
EGFR/HER2/TS-IN-2
- CAS Number: 2444364-04-7
- UNSPSC Description: EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 μM[1].
- Target Antigen: EGFR; Thymidylate Synthase
- Type: Reference compound
- Related Pathways: Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/egfr-her2-ts-in-2.html
- Solubility: 10 mM in DMSO
- Smiles: N#CC1=C(N2N=C(C)C=C2C)N=C(SCC(NC3=NC4=C(S3)C=C(C)C=C4)=O)N=C1C5=CC=CC=C5
- Molecular Weight: 511.62
- References & Citations: [1]Abdellatif KRA, et al. Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS. Bioorg Chem. 2020 Aug;101:103976.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported