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A2AAR/HDAC-IN-2

CAT:
804-HY-143325
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
A2AAR/HDAC-IN-2 - image 1

A2AAR/HDAC-IN-2

  • CAS Number: 2767560-94-9
  • UNSPSC Description: A2AAR/HDAC-IN-2 is a potent A2AAR/HDAC dual inhibitor, with good binding affinity for A2AAR (Ki=10.3 nM) and good inhibitory activity against HDAC1 (IC50=18.5 nM). A2AAR/HDAC-IN-2 can be used in study of antitumor[1].
  • Target Antigen: Adenosine Receptor; HDAC
  • Type: Reference compound
  • Related Pathways: Cell Cycle/DNA Damage;Epigenetics;GPCR/G Protein
  • Applications: Cancer-programmed cell death
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/a2aar-hdac-in-2.html
  • Solubility: 10 mM in DMSO
  • Smiles: NC1=NC(C2=CC=CO2)=C3C=NN(C3=N1)CC4=CC=CC(OCCCCCCC(NO)=O)=C4
  • Molecular Weight: 450.49
  • References & Citations: [1]Zhang J, et al. Dual-acting antitumor agents targeting the A2A adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives. Eur J Med Chem. 2022 Jun 5;236:114326.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported