A2AAR/HDAC-IN-2
CAT:
804-HY-143325
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
A2AAR/HDAC-IN-2
- CAS Number: 2767560-94-9
- UNSPSC Description: A2AAR/HDAC-IN-2 is a potent A2AAR/HDAC dual inhibitor, with good binding affinity for A2AAR (Ki=10.3 nM) and good inhibitory activity against HDAC1 (IC50=18.5 nM). A2AAR/HDAC-IN-2 can be used in study of antitumor[1].
- Target Antigen: Adenosine Receptor; HDAC
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics;GPCR/G Protein
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/a2aar-hdac-in-2.html
- Solubility: 10 mM in DMSO
- Smiles: NC1=NC(C2=CC=CO2)=C3C=NN(C3=N1)CC4=CC=CC(OCCCCCCC(NO)=O)=C4
- Molecular Weight: 450.49
- References & Citations: [1]Zhang J, et al. Dual-acting antitumor agents targeting the A2A adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives. Eur J Med Chem. 2022 Jun 5;236:114326.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported