A2AAR/hMAO-B-IN-1

A2AAR/hMAO-B-IN-1

• CAS Number: 1439488-21-7
• UNSPSC Description: A2AAR/hMAO-B-IN-1 (compoudn 17) is a non-xanthine dual-target inhibitor targeting the A2A adenosine receptor (A2AAR) (IC50: 34.9 nM) andMAO-B (Ki: 39.5 nM, human). A2AAR/hMAO-B-IN-1 inhibits A2AAR-induced cAMP accumulation and exhibits competitive, reversible inhibition of MAO-B. A2AAR/hMAO-B-IN-1 can be used in the study of neurodegenerative diseases such as Parkinson's disease (PD)[1].
• Target Antigen: Adenosine Receptor; Monoamine Oxidase
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/a2aar-hmao-b-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1SC(NC(CCCC2=CC=CC=C2)=O)=NC3=C1C=CC=C3
• Molecular Weight: 324.40
• References & Citations: [1]Stössel A, et al. Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones. J Med Chem. 2013 Jun 13;56(11):4580-96.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported