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Mutated EGFR-IN-3

CAT:
804-HY-130608
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Mutated EGFR-IN-3 - image 1

Mutated EGFR-IN-3

  • CAS Number: 2375107-27-8
  • UNSPSC Description: Mutated EGFR-IN-3 (compound 3) is a potent, ATP-competitive and highly selective allosteric dibenzodiazepinone inhibitor of the EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 values of 12 nM and 13 nM, respectively[1].
  • Target Antigen: EGFR
  • Type: Reference compound
  • Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
  • Applications: Cancer-Kinase/protease
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/mutated-egfr-in-3.html
  • Solubility: 10 mM in DMSO
  • Smiles: O=C1C2=CC(OC3=CC=C(N4CCN(C)CC4)C=C3)=CC=C2NC5=CC=C(F)C=C5N1CC6=CC=CC=C6
  • Molecular Weight: 508.59
  • References & Citations: [1]De Clercq DJH,et al. Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors.ACS Med Chem Lett. 2019 Oct 22;10(11):1549-1553.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported