PROTAC BCR-ABL1 ligand 1

PROTAC BCR-ABL1 ligand 1

• CAS Number: 2489876-34-6
• UNSPSC Description: PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1[1].
• Target Antigen: Bcr-Abl
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-bcr-abl1-ligand-1.html
• Solubility: 10 mM in DMSO
• Smiles: OC1=CC=C(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)C=C1
• Molecular Weight: 347.29
• References & Citations: [1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation. Cancer Res. 2019 Sep 15;79(18):4744-4753.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported