Liproxstatin-1 (hydrochloride)

Liproxstatin-1 (hydrochloride)

• CAS Number: 2250025-95-5
• UNSPSC Description: Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM)[1].
• Target Antigen: Ferroptosis
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/liproxstatin-1-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1.[H]Cl
• Molecular Weight: 377.31
• References & Citations: [1]Friedmann Angeli JP, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014 Dec;16(12):1180-91.|[2]Zilka O, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death. ACS Cent Sci. 2017 Mar 22;3(3):232-243
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported