Capsaicin-d3

Capsaicin-d3

• CAS Number: 1217899-52-9
• UNSPSC Description: Capsaicin-d3 is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].
• Target Antigen: Apoptosis; Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; TRP Channel
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Autophagy;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;Others
• Field of Research: Cancer
• Solubility: 10 mM in DMSO
• Smiles: CC(C)/C=C/CCCCC(NCC1=CC(OC([2H])([2H])[2H])=C(C=C1)O)=O
• Molecular Weight: 308.43
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Anandakumar P, et al. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Jun 6;17(2):254-259.|[3]Shin YH, et al. The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules. 2016 Jun 25;21(7).|[4]McNamara FN, et al. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol. 2005 Mar;144(6):781-90.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported