STAT3-IN-25
CAT:
804-HY-160496-02
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
STAT3-IN-25
- CAS Number: 2591440-75-2
- UNSPSC Description: STAT3-IN-25 (compound 2p) is a potent STAT3 inhibitor with a p-trifluoroethoxy benzyl substituent. STAT3-IN-25 shows STAT3 luciferase inhibition activity using HEK293T cells with an IC50 of 22.3 nM and ATP production inhibition activity using BxPC-3 cells with an IC50 of 32.5 nM. STAT3-IN-25 shows potent antiproliferation activities on BxPC-3 and Capan-2 cells. STAT3-IN-25 has the potential for pancreatic cancer research[1].
- Target Antigen: STAT
- Type: Reference compound
- Related Pathways: JAK/STAT Signaling;Stem Cell/Wnt
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/stat3-in-25.html
- Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(C(N1C)=CC2=C1C=C(OC3=NC=C(C4=NC(C5=CC=C(C(F)(F)F)C=C5)=NO4)N=C3)C=C2)N6CCN(CC7=CC=C(OCC(F)(F)F)C=C7)CC6
- Molecular Weight: 737.65
- References & Citations: [1]Peng He, et al. Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment. J Med Chem. 2022 Nov 24;65(22):15487-15511.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported