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Survivin Antibody / BIRC5

CAT:
800-V4552SAF-100UG
Size:
100 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
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Survivin Antibody / BIRC5

  • Description: The baculovirus protein p35 inhibits virally induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the host s immune system. This is accomplished at least in part by its ability to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino terminal baculovirus IAP repeat (BIR) motif and a carboxy terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs.
  • CAS Number: 9007-83-4
  • UniProt: O15392
  • Host: Mouse
  • Immunogen: A recombinant partial protein sequence (within amino acids 1-142) from the human protein was used as the immunogen for the Survivin antibody.
  • Clonality: Monoclonal
  • Isotype: IgG2b κ
  • Applications: IHC-P
  • Format: Purified
  • Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
  • Reconstitution: Aliquot the Survivin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • Limitations: This Survivin antibody is available for research use only.

Datasheet