(Glu2)-TRH
CAT:
804-HY-P3960-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
(Glu2)-TRH
- CAS Number: 85541-78-2
- UNSPSC Description: (Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].
- Target Antigen: Endogenous Metabolite; Thyroid Hormone Receptor
- Type: Peptides
- Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/glu2-trh.html
- Purity: 99.68
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C([C@@H]1CCC(N1)=O)N[C@@H](CCC(O)=O)C(N2[C@@H](CCC2)C(N)=O)=O
- Molecular Weight: 354.36
- References & Citations: [1]Vien Nguyen, et al. [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82(1-2):83-6.
- Shipping Conditions: Blue Ice
- Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
- Clinical Information: No Development Reported