(Glu2)-TRH

(Glu2)-TRH

• CAS Number: 85541-78-2
• UNSPSC Description: (Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS[1].
• Target Antigen: Endogenous Metabolite; Thyroid Hormone Receptor
• Type: Peptides
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/glu2-trh.html
• Purity: 99.68
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C([C@@H]1CCC(N1)=O)N[C@@H](CCC(O)=O)C(N2[C@@H](CCC2)C(N)=O)=O
• Molecular Weight: 354.36
• References & Citations: [1]Vien Nguyen, et al. [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82(1-2):83-6.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported